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Serum/plasma mass concentration of total bilirubin

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of bilirubin in your blood, a byproduct of red blood cell breakdown that your liver helps process. Bilirubin is important for your body’s waste removal system.

Quick summary

["Bilirubin helps identify liver function and blood disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
101088-3
Short code
Ge3 Ab SerPl Ql
Synonyms
Ge3 Ab SerPl Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for liver disease, such as hepatitis, cirrhosis, or bile duct blockages. It can also help diagnose conditions like hemolytic anemia, where red blood cells break down faster than usual. Sometimes, it’s used to monitor treatment progress or screen for genetic disorders affecting bilirubin metabolism.

What to Expect Before the Test

No special preparation is needed. You may have a blood sample drawn from a vein in your arm, similar to other blood tests. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

High bilirubin levels may suggest liver problems, jaundice (yellowing of skin/eyes), or other conditions affecting red blood cell breakdown. Low levels are less common but could indicate liver disease or certain genetic conditions. Your provider will discuss results in the context of your health history.

Common Conditions Linked to Bilirubin Levels

Elevated bilirubin is often linked to liver issues (e.g., hepatitis, gallstones), red blood cell disorders (e.g., anemia), or blockages in the bile ducts. Low levels are rare but may signal liver dysfunction or specific genetic disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is critical for diagnosing and managing conditions affecting bilirubin metabolism, liver function, or blood breakdown. It helps guide treatment plans, such as managing jaundice in newborns or monitoring chronic liver diseases.

Short name

Total bilirubin

Frequently asked questions

What causes high bilirubin levels?
High bilirubin can result from liver problems (e.g., inflammation, scarring), blocked bile ducts, or conditions where red blood cells break down too quickly (e.g., anemia). Jaundice, a yellowing of skin/eyes, is a common symptom.
What causes low bilirubin levels?
Low bilirubin is less common and may occur with liver disease (e.g., cirrhosis), certain medications, or genetic disorders affecting bilirubin processing. Your provider will investigate further if results are unusually low.
Can diet affect bilirubin test results?
Dietary changes rarely impact bilirubin levels directly, but avoiding alcohol or certain medications (e.g., antibiotics) before the test may help ensure accurate results. Follow your provider’s instructions.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy