Glutathione Peroxidase Activity in Serum or Plasma
This test measures the activity level of glutathione peroxidase, an enzyme that helps protect cells from oxidative damage by neutralizing harmful free radicals.
["Glutathione peroxidase helps your body defend against oxidative stress; results may be checked if you have conditions linked to oxidative damage or certain metabolic disorders."]
Key facts at a glance
- LOINC
- 53432-1
- Short code
- GGT Dial fld-cCnc
- Synonyms
- GGT Dial fld-cCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 8
- Ref high
- 61
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82977
- SNOMED
- 3110003
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
Glutathione peroxidase is an antioxidant enzyme found in many cells. It works by converting hydrogen peroxide into water, reducing oxidative stress that can damage DNA, proteins, and lipids. This test evaluates its functional capacity in your blood.
Why Might You Need This Test?
Your doctor may order this test if you have symptoms or conditions associated with oxidative stress, such as chronic fatigue, autoimmune diseases, or metabolic disorders. It may also be part of broader metabolic or antioxidant screening.
What to Expect Before the Test
No special preparation is typically required. You may fast for 8–12 hours before the blood draw if instructed, but always follow your healthcare provider’s specific instructions.
How Is the Test Performed?
A healthcare professional will draw blood from a vein in your arm. The sample is then analyzed in a lab to measure enzyme activity using specialized techniques like enzymatic assays.
Reference range
Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A
No special preparation required. Avoid fatty meals before the test if possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Glutathione Peroxidase Activity
Frequently asked questions
Low levels of glutathione peroxidase may indicate increased oxidative stress, which can be linked to chronic diseases like cardiovascular conditions, certain cancers, or neurodegenerative disorders. High levels could suggest certain metabolic or genetic conditions but are less commonly evaluated in isolation.
What Are Normal Results?
Does This Test Require Follow-Up?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy