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Plasma or serum concentration of total protein (mass concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins.

Quick summary

["Total protein helps assess overall protein balance and potential kidney or liver issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49944-2
Short code
GH 10 PM SerPl-aCnc
Synonyms
GH 10 PM SerPl-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions affecting protein levels, such as kidney disease, liver problems, malnutrition, or certain infections. It can also help monitor protein loss due to conditions like nephrotic syndrome or severe burns.

What to Expect Before the Test

No special preparation is needed, but you may fast if instructed. Wear comfortable clothing and avoid heavy exercise before the draw. Bring any medications or supplements you’re taking to discuss with your provider.

What the Test Involves

A healthcare professional will draw blood from a vein in your arm. You may feel a slight pinch, but it usually takes only a few minutes. The blood sample is sent to a lab for analysis.

What the Results Mean

Results are compared to a general reference range, but exact values depend on the lab. Low protein levels may indicate malnutrition, kidney disease, or liver dysfunction, while high levels could suggest dehydration, inflammation, or certain medical conditions like multiple myeloma.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

What Are Common Causes of Abnormal Results?
Low total protein levels can result from kidney disease (e.g., nephrotic syndrome), liver cirrhosis, severe malnutrition, or excessive protein loss (e.g., from burns or chronic diarrhea). High levels may signal dehydration, chronic inflammation, or conditions like multiple myeloma.
How Often Should I Get This Test?
Your provider will determine frequency based on your health status. Regular monitoring may be needed if you have ongoing conditions like kidney disease or liver issues.
Can I Eat or Drink Before the Test?
Check with your provider, but generally, fasting is not required unless specified. Avoid caffeine or heavy meals 2 hours before the draw if instructed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy