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Total Protein with Albumin/Globulin Ratio (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures your blood’s total protein levels and evaluates the balance between albumin and globulin proteins, which are key to maintaining fluid balance, immune function, and tissue health.

Quick summary

["Helps assess protein metabolism, kidney function, and potential nutritional deficiencies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47893-3
Short code
GH 1h p Gc SerPl-aCnc
Synonyms
GH 1h p Gc SerPl-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Total protein combines albumin and globulin proteins found in your blood. Albumin helps regulate fluid distribution in your body, while globulins support immune function and transport certain substances. The ratio between these proteins can indicate underlying health conditions, such as liver disease or kidney problems.

Why Is This Test Done?

Your doctor may order this test to check for conditions like malnutrition, liver disease, kidney disease, or chronic inflammation. It can also help monitor treatment effectiveness for conditions affecting protein production or breakdown.

Common Conditions Monitored

Abnormal results may signal conditions such as protein-losing disorders, liver cirrhosis, or severe infections. High protein levels might suggest dehydration or certain cancers, while low levels could indicate malnutrition or kidney disease.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is processed to separate serum (if drawn without an anticoagulant) or plasma (if drawn with an anticoagulant). This sample is then analyzed in a lab using specialized techniques to measure protein components.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Protein profile test

Frequently asked questions

How might my results affect my health?
Your results will be compared to standard ranges for your age and sex. Low total protein or abnormal albumin-to-globulin ratios may signal conditions needing further evaluation, such as liver or kidney dysfunction. High levels could warrant investigation into dehydration or other metabolic issues. Always discuss your results with your healthcare provider for personalized interpretation.
What can I do to prepare for this test?
No special preparation is usually needed, but avoid heavy meals or alcohol 24 hours before the test. If you’re on blood thinners, inform your doctor beforehand, as it may affect blood collection.
Will this test hurt?
The blood draw may cause mild discomfort or bruising at the site, but it typically doesn’t cause significant pain. Most people tolerate it well, and the procedure takes only a few minutes.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy