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Serum or plasma mass concentration of total protein

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood serum or plasma, which helps assess overall protein levels in your body.

Quick summary

["Total protein levels reflect your body’s protein balance and can indicate hydration, liver function, or nutritional status."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46410-7
Short code
GH 30M p Arg SerPl-mCnc
Synonyms
GH 30M p Arg SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to check for conditions like dehydration, liver disease, kidney problems, or malnutrition. It can also help monitor protein loss due to conditions like kidney disease or certain cancers.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a liver or kidney evaluation. Bring any medications you’re taking.

What the Results Mean

Higher-than-normal levels might suggest conditions like dehydration, multiple myeloma, or severe liver disease. Lower-than-normal levels could indicate malnutrition, kidney disease, or liver problems.

Common Conditions Monitored

This test is often used alongside others to diagnose or track conditions like chronic kidney disease, liver cirrhosis, or protein-losing disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Elevated total protein may indicate overproduction of proteins (e.g., monoclonal gammopathy) or dehydration, while low levels often signal protein loss (e.g., nephrotic syndrome) or inadequate dietary intake. Always discuss results with your provider for personalized interpretation.

Short name

Total Protein

Frequently asked questions

What causes abnormal protein levels?
Abnormal results can stem from conditions like kidney disease (leading to protein loss), liver disease (affecting protein synthesis), or severe dehydration. Medications, infections, or certain cancers may also play a role.
How often should I get this test?
Frequency depends on your health status. Your provider may recommend regular checks if you have conditions like kidney disease, liver disease, or malnutrition. Follow-up may be needed every few months or annually.
Does diet affect protein test results?
Yes, diet can influence protein levels. High-protein diets may temporarily raise levels, while poor nutrition or excessive fluid loss can lower them. Avoid extreme dietary changes before testing unless directed by your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy