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Beta-2-Microglobulin, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of beta-2-microglobulin, a small protein found in your blood that helps identify how well your kidneys are filtering waste products.

Quick summary

Beta-2-microglobulin levels can help assess kidney function and monitor conditions affecting protein waste clearance.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
48129-1
Short code
GH 30M Pre betaxolol+Gc SerPl-aCnc
Synonyms
GH 30M Pre betaxolol+Gc SerPl-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have kidney disease, certain cancers (like multiple myeloma), or if you’re undergoing dialysis. It can also help track how well your kidneys are working over time.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re on dialysis, your blood may be drawn during or after your session.

How the Test Results Are Used

Higher than normal levels may suggest kidney problems or conditions that cause abnormal protein release, while lower levels could indicate overproduction of this protein.

Common Conditions Monitored

This test is often used to monitor kidney function in chronic kidney disease, multiple myeloma, or other conditions affecting protein metabolism.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Elevated levels may indicate impaired kidney function or conditions like multiple myeloma, where abnormal protein production occurs. Lower levels alone may not be clinically significant without clinical context.

Short name

Beta-2-Microglobulin (Serum)

Frequently asked questions

What causes beta-2-microglobulin levels to change?
Kidney disease, certain cancers (like multiple myeloma), or conditions affecting protein metabolism can alter beta-2-microglobulin levels. Stress, dehydration, or medications may also influence results.
Can diet affect this test?
Dietary changes alone typically won’t significantly impact beta-2-microglobulin levels, but kidney-friendly diets (if applicable) may indirectly support kidney health.
How often should I get this test?
Your healthcare provider will determine the frequency based on your medical condition. Regular monitoring may be needed if you have chronic kidney disease or cancer.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy