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C-reactive protein (CRP) mass concentration in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of C-reactive protein, a protein produced by the liver in response to inflammation in the body.

Quick summary

["CRP helps identify and monitor inflammation, often used to assess infection, injury, or autoimmune conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
56565-5
Short code
GH 9h p chal SerPl-mCnc
Synonyms
GH 9h p chal SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order CRP tests to check for signs of inflammation, monitor chronic conditions like rheumatoid arthritis or lupus, or evaluate symptoms such as fever, pain, or swelling that could indicate infection, injury, or other health issues. It’s also used in some risk assessments for heart disease.

What Does a High CRP Level Mean?

Elevated CRP levels often signal inflammation. While high levels can point to infections (like pneumonia or urinary tract infections), they may also appear in conditions like heart disease, certain cancers, or autoimmune diseases. Your doctor will consider your symptoms and other test results to interpret the results.

What Does a Low CRP Level Mean?

Low CRP levels typically mean there is little to no active inflammation in your body. However, very low levels might raise concerns if you have a chronic condition that usually requires monitoring CRP, so always discuss results with your healthcare provider.

How Is This Test Performed?

A blood sample is taken from a vein, usually in your arm. The blood is then sent to a lab where it is processed to separate serum or plasma. The CRP protein is measured using a sensitive lab technique to detect its concentration.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CRP (Serum/Plasma)

Frequently asked questions

What causes CRP levels to be high?
High CRP levels can be caused by infections (such as bacterial infections), injuries, surgeries, or medical conditions like rheumatoid arthritis, lupus, or heart disease. Stress, certain medications, or even pregnancy may also influence CRP levels.
What should I do if my CRP test is abnormal?
If your CRP test result is higher than expected, your doctor may recommend further testing or adjustments to your treatment plan. They could also order additional tests to identify the cause of inflammation or guide treatment options, such as antibiotics for infections or anti-inflammatory medications for autoimmune conditions.
Can CRP levels change over time?
Yes, CRP levels can fluctuate depending on your health status, recent illnesses, medications, or lifestyle factors like diet and exercise. Regular monitoring may be needed for chronic conditions, and your doctor will help interpret any changes in your results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy