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Serum/plasma substance concentration for a specific protein marker (likely related to complement system)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of a protein involved in the immune system’s complement pathway, which helps protect the body from infections and inflammation.

Quick summary

["Understanding your complement protein levels can help identify immune system function or potential health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
25529-9
Short code
GH SerPl-sCnc
Synonyms
GH SerPl-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects the concentration of a specific complement component in your blood, which plays a role in immune defense. This protein is part of a cascade that helps clear pathogens and regulate inflammation. While the exact protein may vary by lab, it is often linked to conditions affecting immune response or chronic inflammation.

Why It’s Done

Your healthcare provider may order this test if you have symptoms like frequent infections, autoimmune conditions, or signs of overactive inflammation. It can also help diagnose or monitor certain inherited or acquired immune disorders.

Common Reasons for Testing

Possible triggers include suspected immune deficiencies, unexplained infections, or conditions like lupus, vasculitis, or chronic inflammatory diseases. Some labs may also use it to screen for genetic complement disorders.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in your arm. The blood is processed to separate serum or plasma, which is then sent to the lab for analysis. You may be asked to fast or avoid certain medications before the test, depending on the lab’s instructions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal levels of this complement protein can indicate immune system dysfunction. Low levels may suggest inherited deficiencies or chronic immune activation, while high levels could point to acute infections, inflammation, or certain autoimmune diseases. Early detection helps guide treatment decisions, such as immune-modulating therapies.

Short name

None

Frequently asked questions

What does a low level of this protein mean?
A low level may signal an inherited complement deficiency, chronic immune activation, or conditions like lupus or vasculitis. Your doctor will consider your symptoms and other test results to determine the cause and next steps.
What does a high level indicate?
High levels are often seen during acute infections or inflammatory processes. They may also appear in certain autoimmune conditions or after exposure to immune-stimulating factors. Further evaluation may include additional blood tests or clinical correlation.
How often should I get this test?
Frequency depends on your health status and symptoms. If you have a known immune disorder, your doctor may recommend regular monitoring. If this test is part of a routine check, follow their guidance on timing and intervals.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy