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Serum or Plasma Total Protein by Bromocresol Green (BCG) Method

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes both albumin and globulin proteins. Proteins help maintain fluid balance, support immune function, and transport nutrients.

Quick summary

["Total protein levels can indicate overall health, hydration status, or potential liver/kidney issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58949-9
Short code
GH sp12 SerPl-mCnc
Synonyms
GH sp12 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to check for conditions affecting protein production, such as liver disease, kidney problems, malnutrition, or certain immune disorders. It can also help monitor fluid balance or diagnose conditions like nephrotic syndrome or severe dehydration.

What to Expect Before the Test

No special preparation is needed unless instructed by your provider. You may have a small needle inserted into your arm or vein to draw blood. If you’re on a blood thinner, let your provider know to avoid unnecessary bleeding.

What the Results Mean

Results are compared to standard ranges, but exact values depend on lab methods. Low protein levels may suggest malnutrition or organ dysfunction, while high levels could indicate dehydration or conditions like multiple myeloma.

Common Conditions Affecting Results

Low protein levels might be linked to liver disease (reducing albumin), kidney disease (losing protein in urine), or severe infections. High levels could result from dehydration or certain cancers.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

Will I feel any pain or discomfort during the blood draw?
You may feel a slight pinch or sting when the needle is inserted, but most people describe it as mild. Some people experience a small bruise or slight swelling afterward.
Can diet affect my protein test results?
Dietary protein intake can influence results, so avoid high-protein meals 24 hours before testing if your provider recommends it. Hydration status also matters—drink enough fluids but don’t overdo it.
What if my protein levels are out of range?
If your results are abnormal, your provider will discuss possible causes and next steps, such as further testing (e.g., albumin, kidney function) or lifestyle changes to address underlying issues.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy