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Serum/plasma mass concentration of total protein

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which helps assess overall protein levels and kidney function.

Quick summary

["Total protein helps doctors check for conditions affecting protein balance or kidney health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58855-8
Short code
GH sp13 SerPl-mCnc
Synonyms
GH sp13 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Total Protein Used For?

Total protein includes both albumin and globulin proteins. It’s often measured to evaluate kidney function (since kidneys filter proteins) and to diagnose conditions like malnutrition, liver disease, or certain infections. Low levels may indicate kidney problems or protein loss, while high levels could suggest dehydration or conditions like multiple myeloma.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is then processed to separate serum or plasma, where protein concentration is measured using a specialized lab technique.

What Are Common Results and Their Meanings?

Results are typically reported in grams per deciliter (g/dL). While exact reference ranges vary by lab, lower-than-normal levels may signal protein loss, kidney issues, or malnutrition, while higher-than-normal levels might suggest dehydration or other systemic conditions.

When Might You Need This Test?

Your doctor may order this test if you have symptoms like swelling (edema), unexplained weight loss, fatigue, or if they suspect conditions like kidney disease, liver disease, or chronic infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

Why might my total protein test result be different from what I expected?
Several factors can influence results, including recent fluid intake, diet, kidney function, liver health, and certain medications. If you suspect an issue, discuss your results with your healthcare provider.
What should I do if my total protein test is abnormal?
If your results are outside the expected range, your doctor may recommend further testing or adjustments to your treatment plan. They’ll review your medical history and other test results to determine the next steps.
Does diet affect total protein test results?
Yes, diet can influence protein levels. High-protein diets or certain medical conditions may temporarily alter results. Your doctor may ask about your diet if they suspect dietary factors played a role.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy