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Glucose in Serum or Plasma (24-Hour Profile)

Published: August 9, 2026Updated: August 16, 2026

This test measures your blood glucose levels over a 24-hour period using a sample of your serum or plasma. It helps track how your body manages glucose throughout the day.

Quick summary

["Understanding how your body handles glucose over time can help manage diabetes or other conditions affecting blood sugar levels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
27838-2
Short code
GH sp14 p chal SerPl-mCnc
Synonyms
GH sp14 p chal SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have diabetes, prediabetes, or symptoms like frequent urination, extreme thirst, or unexplained weight changes. It may also be used to assess how well medications are working or to diagnose conditions like hypoglycemia or insulin resistance.

How the Test Works

During this test, blood samples are collected at multiple intervals over 24 hours. The samples are analyzed to measure glucose concentration in your blood. The results help create a profile of your glucose levels throughout the day.

What to Expect Before the Test

You’ll need to follow specific instructions, such as maintaining your usual diet and activity level, but avoiding certain foods or drinks that could affect glucose levels. You may be asked to collect urine or blood samples at home or in a clinic.

What to Expect During the Test

Blood samples are drawn at set times, often including before meals and after meals, to capture glucose levels naturally. The process is usually quick and painless, similar to a regular blood draw.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test provides a detailed picture of how your body regulates glucose, which is crucial for diagnosing diabetes, managing blood sugar control, and evaluating the effectiveness of treatments. Abnormal results may indicate conditions like hypoglycemia, insulin resistance, or poor metabolic control.

Short name

24-Hour Glucose Monitoring

Frequently asked questions

What does a 24-hour glucose profile tell me about my health?
It shows how your blood sugar levels fluctuate naturally over time, helping identify patterns that may indicate diabetes, insulin issues, or how well your body responds to meals and medications.
How often should I get this test?
Your healthcare provider will determine the frequency based on your medical condition, treatment plan, and overall health. Regular monitoring may be recommended for people with diabetes or those at risk.
Can I eat or drink anything before the test?
Follow your provider’s instructions carefully. Typically, you’ll avoid foods or drinks that could affect glucose levels, such as sugary beverages or snacks, but some tests may allow small amounts of water or specific meals.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy