Serum or Plasma Total Protein Mass Concentration

What Is Total Protein Used For?

Total protein is commonly checked to evaluate kidney function, detect liver disease, monitor nutritional status, or identify conditions like nephrotic syndrome or severe dehydration. It can also help diagnose conditions affecting protein synthesis or loss (e.g., malnutrition, certain cancers).

How Is the Test Performed?

A blood sample is drawn from a vein, typically in your arm. The sample is then sent to a lab where protein levels are measured using a specialized test that separates and quantifies proteins in the serum or plasma.

What Are Common Causes of Abnormal Results?

Low total protein may indicate malnutrition, kidney disease, liver problems, or excessive protein loss (e.g., from chronic diarrhea or kidney filtration issues). High levels could suggest dehydration, multiple myeloma, or conditions that increase protein production (e.g., severe infections).

How Often Is This Test Done?

This test is often ordered as part of a routine blood panel, during evaluations for kidney or liver disease, or when symptoms like swelling, weight loss, or fatigue are present. Your healthcare provider may repeat it if you’re undergoing treatment for conditions affecting protein levels.