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Serum/plasma mass concentration of total protein

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps assess overall protein levels in your serum or plasma.

Quick summary

["Total protein helps doctors check for conditions affecting protein balance, like kidney disease or malnutrition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58843-4
Short code
GH sp24 SerPl-mCnc
Synonyms
GH sp24 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to evaluate kidney function, detect liver disease, identify malnutrition, or monitor conditions like chronic kidney disease or protein-losing syndromes. It can also help diagnose or monitor certain cancers or inflammatory diseases.

What Does a Result Mean?

Higher-than-normal results might suggest conditions like dehydration, multiple myeloma, or severe liver disease. Lower-than-normal results could indicate malnutrition, kidney disease, or liver problems. Your results will be interpreted in relation to your overall health and symptoms.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is then separated into serum (liquid after clotting) or plasma (liquid after anticoagulant use) for testing. This test does not require fasting unless specified by your provider.

Common Conditions Monitored

This test is often used to monitor conditions such as kidney disease, liver disease, malnutrition, and certain cancers. It can also help assess hydration status and identify protein loss due to conditions like inflammatory bowel disease.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What factors can affect my total protein test results?
Several factors may influence your results, including diet (especially protein intake), kidney or liver disease, dehydration, certain medications, pregnancy, or chronic illnesses like diabetes. If you have recent illnesses, infections, or changes in diet, let your healthcare provider know.
How often should I get this test?
The frequency depends on your health condition and treatment plan. Your provider will determine how often you need this test based on your specific needs, such as monitoring chronic diseases or response to treatment.
Can I eat or drink before this test?
Generally, no special preparation is needed, but some providers may ask you to fast or avoid certain foods/drinks. Always follow your healthcare provider’s instructions for the best results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy