Skip to content

Serum/Plasma Mass Concentration of Prostate-Specific Antigen (PSA)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of prostate-specific antigen, a protein produced by both healthy and cancerous prostate cells, in your blood.

Quick summary

["PSA helps assess prostate health and detect potential prostate issues, including cancer."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
50494-4
Short code
GH sp2 SerPl-mCnc
Synonyms
GH sp2 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order a PSA test to monitor prostate health, especially if you have symptoms like frequent urination, pain during urination, or an enlarged prostate. It can also be used to screen for prostate cancer, especially in men at higher risk. Some tests are done as part of routine check-ups, while others are triggered by specific symptoms or family history.

What to Expect Before the Test

No special preparation is needed, but you may be asked to avoid ejaculation for 2–7 days before the test. Drinking water is fine, but avoid alcohol or strenuous activity that day. Bring any medications you’re currently taking.

What Happens During the Test

A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a slight pinch, but it usually takes only a few seconds. The blood sample is then sent to a lab for analysis.

What the Results Mean

PSA levels vary by age, health, and other factors. A single test result alone doesn’t diagnose prostate cancer, but it can signal areas for further evaluation, such as imaging or additional tests. Your doctor will interpret results in the context of your overall health and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated PSA levels can indicate prostate inflammation, infection, benign prostatic hyperplasia (BPH), or prostate cancer. While higher levels raise concern, they’re not definitive proof of cancer. Other conditions, like urinary tract infections or prostate surgery, can also affect PSA. Regular monitoring and follow-up testing may be recommended based on your results and symptoms.

Short name

PSA Level

Frequently asked questions

What causes PSA levels to change?
PSA levels can rise due to prostate inflammation, infections, benign growths (like BPH), or prostate cancer. Other factors, such as ejaculation, recent prostate exams, or certain medications, can temporarily affect results. If you’ve had recent prostate procedures or treatments, let your doctor know to avoid misleading interpretations.
How often should I get a PSA test?
The frequency depends on your age, risk factors, and doctor’s recommendation. For men under 50 with no risk factors, tests are often recommended every 2–5 years. Men over 50 or with a family history of prostate cancer may get tested more often. Discuss personalized timing with your healthcare provider.
Can PSA levels be affected by diet or lifestyle?
Dietary factors like cruciferous vegetables (e.g., broccoli, Brussels sprouts) or high-fat foods may have *mild* effects on PSA levels, but the impact is usually small. Lifestyle changes like exercise or weight management may support overall prostate health but don’t directly alter PSA test results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy