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Serum/Plasma Mass Concentration of Serum Protein (General Protein Measurement)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which helps assess overall protein levels in serum or plasma.

Quick summary

["Protein levels in your blood can give important clues about your health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58876-4
Short code
GH sp31 SerPl-mCnc
Synonyms
GH sp31 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to evaluate conditions affecting protein synthesis, breakdown, or kidney function. It can also help diagnose or monitor diseases like liver disease, malnutrition, or kidney problems. Sometimes, it’s used to check for protein-losing conditions, such as certain types of heart or lung disease.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for a few hours before the test if it’s part of a more complex evaluation, but this is not always the case. Your blood will be drawn from a vein, typically in your arm, and you may feel a brief pinch or slight discomfort.

What the Test Results Mean

Results are compared to standard ranges for healthy adults. Low protein levels may indicate malnutrition, liver or kidney disease, or excessive protein loss. High levels could suggest dehydration, inflammation, or certain medical conditions. Your doctor will interpret the results in the context of your overall health and symptoms.

Common Conditions Monitored

This test is often used to monitor conditions like chronic kidney disease, liver cirrhosis, severe infections, or inflammatory diseases. It may also be part of routine check-ups for people with known protein-related disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

What causes low protein levels in blood?
Low protein levels can result from conditions that affect the liver (like cirrhosis), kidney disease, severe infections, or malnutrition. It may also occur if the body loses protein through excessive sweating, vomiting, or diarrhea. Certain medications or genetic disorders can also play a role.
What causes high protein levels in blood?
High protein levels can be due to dehydration, severe inflammation, or certain cancers. In some cases, it may be a normal finding if you have a high-protein diet. Your doctor will review your symptoms and other test results to determine the cause.
How often should I get this test?
The frequency depends on your health status and any underlying conditions. If you have a chronic illness like kidney disease or liver disease, your doctor may recommend regular testing. Otherwise, this test is usually not part of routine check-ups unless you have symptoms or risk factors.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy