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Serum or Plasma Mass Concentration of Serum Protein (General Protein Measurement)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein found in your blood serum or plasma. Proteins are essential for many bodily functions, including transporting nutrients, maintaining fluid balance, and supporting immune responses.

Quick summary

["This test helps assess overall protein levels in your blood, which can indicate hydration status, kidney function, or other health conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58875-6
Short code
GH sp32 SerPl-mCnc
Synonyms
GH sp32 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test to evaluate your hydration status, check for kidney disease, monitor liver function, or assess protein loss due to conditions like kidney failure, malnutrition, or certain inflammatory diseases.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if it involves a blood draw, but this depends on your provider’s instructions. Avoid strenuous activity or excessive fluid intake 24 hours prior if specified.

What the Test Involves

A small needle will be inserted into a vein in your arm to draw blood. The process is quick and typically causes only mild discomfort. The sample is then sent to a lab for analysis.

What the Results Mean

Lower-than-expected protein levels may suggest dehydration, malnutrition, or kidney problems, while very high levels could indicate conditions like multiple myeloma or severe liver disease. Your results will be interpreted in relation to your overall health and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal results may prompt further testing, such as additional protein breakdown tests (e.g., albumin or globulin levels), kidney function tests (e.g., creatinine), or imaging studies. Your provider will discuss findings and recommend follow-up based on your symptoms and test results.

Frequently asked questions

How often should I expect this test?
The frequency depends entirely on your healthcare provider’s recommendations. Some patients may need this test annually or more often if they have chronic conditions like kidney disease or liver issues.
What are the most common causes of low or high protein levels?
Low protein levels can result from poor nutrition, kidney disease, severe infections, or excessive vomiting/diarrhea. High protein levels may be linked to conditions like multiple myeloma, severe dehydration, or certain cancers.
Can diet affect the results of this test?
Yes, diet can influence protein levels. High-protein diets or certain medical diets (e.g., low-sodium) may temporarily alter results. Follow your provider’s instructions regarding fasting or dietary restrictions before testing.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy