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Serum or plasma mass concentration of protein (general protein measurement)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which helps assess overall protein levels in serum or plasma.

Quick summary

["Protein levels in your blood can give clues about your health, including kidney function and hydration status."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58872-3
Short code
GH sp36 SerPl-mCnc
Synonyms
GH sp36 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions affecting protein levels, such as kidney disease, liver problems, or dehydration. It can also help monitor treatments for conditions like burns or severe infections.

What Does the Result Mean?

Higher-than-normal protein levels might indicate conditions like multiple myeloma or dehydration. Lower-than-normal levels could suggest kidney disease, liver issues, or malnutrition. Your results will be interpreted by your doctor based on your overall health.

Common Conditions Monitored

This test is often used to monitor kidney function, detect liver disease, or evaluate protein loss in conditions like nephrotic syndrome.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The blood is then separated into serum (liquid part after clotting) or plasma (liquid part without clotting) for testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Protein Levels in Blood

Frequently asked questions

What causes protein levels to be too high or too low?
High protein levels may be due to conditions like dehydration, multiple myeloma, or certain cancers. Low protein levels can result from kidney disease, liver failure, or poor nutrition.
How often should I get this test?
Your doctor will determine how often you need this test based on your medical history, symptoms, and treatment plan. Regular monitoring may be necessary if you have ongoing health conditions.
Can diet affect protein test results?
Yes, diet can influence protein levels. Eating a balanced diet rich in proteins may help maintain normal levels, but your doctor should assess if dietary changes are appropriate for your specific health needs.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy