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Serum/plasma mass concentration of serum protein (total protein)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, including albumin and other proteins like globulins.

Quick summary

["Total protein helps assess overall protein balance and potential nutritional or kidney issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58869-9
Short code
GH sp39 SerPl-mCnc
Synonyms
GH sp39 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order a total protein test to check for conditions affecting protein production, such as liver disease, kidney problems, or malnutrition. It can also help diagnose conditions like multiple myeloma or certain autoimmune diseases.

What Does the Result Mean?

Higher-than-normal levels might suggest conditions like dehydration, liver disease, or certain cancers. Lower-than-normal levels could indicate malnutrition, kidney disease, or excessive protein loss.

Common Conditions Monitored

This test is often used to monitor protein levels in patients with chronic kidney disease, liver disorders, or those receiving certain treatments like chemotherapy.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is then separated into serum or plasma for testing. You may be asked to fast before the test if instructed by your doctor.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes high total protein levels?
High protein levels can result from conditions like severe dehydration, liver disease, or certain cancers. Chronic kidney disease or overactive thyroid can also contribute. Your doctor will consider your full medical history and other test results to determine the cause.
What causes low total protein levels?
Low protein levels often occur due to malnutrition, kidney disease, or excessive protein loss through urine (e.g., nephrotic syndrome). Liver problems or certain medications may also lead to lower protein levels. Always discuss symptoms and medical history with your healthcare provider.
How often should this test be repeated?
The frequency depends on your health condition. If you have an ongoing issue like kidney or liver disease, your doctor may recommend periodic testing to monitor changes in your protein levels. Follow-up schedules are tailored to your specific needs.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy