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Serum or plasma mass concentration of total protein

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps your body build tissues, fight infections, and maintain fluid balance.

Quick summary

["Total protein levels can indicate overall health and help diagnose conditions like dehydration, liver disease, or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58860-8
Short code
GH sp48 SerPl-mCnc
Synonyms
GH sp48 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions affecting protein levels, such as kidney disease, liver disease, malnutrition, or dehydration. It can also be used to monitor certain treatments or conditions like multiple myeloma or nephrotic syndrome.

What Does the Result Mean?

Results are not provided with specific numeric ranges. High levels may suggest conditions like dehydration or chronic liver disease, while low levels might indicate malnutrition, kidney disease, or liver problems. Your provider will interpret the result in the context of your overall health and symptoms.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate serum (if drawn without anticoagulants) or plasma (if drawn with anticoagulants) for testing. This test does not require fasting.

Common Conditions Monitored

This test is often used to monitor conditions like chronic kidney disease, liver disease (such as cirrhosis), malnutrition, or to assess the effectiveness of treatments for conditions affecting protein synthesis or loss.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Total Protein Levels

Short name

Total Protein

Frequently asked questions

What causes high total protein levels?
High total protein levels can be due to dehydration, chronic liver disease, multiple myeloma, or certain types of infections. Your provider will review your symptoms and other test results to determine the cause.
What causes low total protein levels?
Low total protein levels are often linked to malnutrition, kidney disease, liver disease, or conditions causing excessive protein loss (e.g., nephrotic syndrome). Chronic inflammation or certain medications may also contribute.
How often should this test be repeated?
The frequency depends on your medical condition and treatment plan. Your healthcare provider will decide how often to repeat this test based on your specific situation and symptoms.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy