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Serum or plasma mass concentration of growth hormone (GH) binding protein (GHBP)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of a protein that binds to growth hormone in your blood, which can help assess how well your body is responding to growth hormone.

Quick summary

["GHBP helps evaluate pituitary function and potential growth hormone resistance or deficiency."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
50496-9
Short code
GH sp4 SerPl-mCnc
Synonyms
GH sp4 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Growth Hormone Binding Protein (GHBP)?

GHBP is a protein produced by your liver that binds to growth hormone (GH) in the blood. It’s a marker that reflects how much free (unbound) GH is available to affect growth and metabolism. Levels can be influenced by conditions like pituitary disorders, obesity, or certain genetic factors.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms of growth hormone issues (e.g., slow growth in children, muscle weakness, or metabolic problems) or if you’re being treated with growth hormone therapy. It can also help monitor how well your body is responding to treatment.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The sample is then processed to separate serum or plasma, where the GHBP protein is measured using a specialized immunoassay technique.

What Does the Test Result Mean?

Results are not provided with specific reference ranges, as they depend on clinical context (e.g., age, treatment status). Your doctor will interpret the result in relation to your symptoms and other tests.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

GH Binding Protein (GHBP)

Frequently asked questions

What causes abnormal GHBP levels?
Abnormal GHBP levels can result from conditions like pituitary tumors, growth hormone deficiency, acromegaly (excess GH), obesity, or genetic disorders affecting GH signaling. Your doctor will consider your medical history and other test results to determine the cause.
How often should I get this test?
Frequency depends on your medical needs. If you’re being monitored for growth hormone-related conditions, your doctor may recommend testing every few months or as needed to track changes.
Can lifestyle changes affect GHBP levels?
Yes, factors like diet, exercise, and weight can influence GH levels and indirectly affect GHBP. Maintaining a healthy weight and engaging in regular physical activity may support normal hormone function.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy