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Serum/plasma mass concentration of total protein

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps assess overall protein levels and kidney function.

Quick summary

["Total protein levels can signal kidney issues or nutritional deficiencies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
50497-7
Short code
GH sp5 SerPl-mCnc
Synonyms
GH sp5 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to check for conditions like kidney disease, liver problems, malnutrition, or dehydration. It can also help monitor long-term health, especially in people with chronic illnesses.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm or vein to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Higher-than-normal results may indicate liver disease, kidney problems, or dehydration. Lower-than-normal results could suggest malnutrition, severe burns, or overhydration. Your provider will interpret results in the context of your health history.

Common Conditions Linked to Results

Abnormal protein levels can signal conditions like chronic kidney disease, liver cirrhosis, or conditions affecting protein absorption (e.g., celiac disease). Always discuss results with your doctor.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes high protein levels in my blood?
High protein levels can result from conditions like liver disease, dehydration, or certain infections. Severe burns or kidney issues may also contribute. Your doctor will review your symptoms and other test results to determine the cause.
What causes low protein levels in my blood?
Low protein levels often occur due to malnutrition, kidney disease, liver problems, or conditions that prevent protein absorption (e.g., severe diarrhea or malabsorption). Chronic illnesses like cancer or inflammatory diseases may also play a role.
Can diet affect my protein test results?
Yes, diet can influence protein levels. Eating a balanced diet with adequate protein may help maintain normal levels. Avoiding extreme diets or nutritional deficiencies can support stable results. Always follow your doctor’s advice regarding diet and testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy