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Serum/plasma mass concentration of total protein

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps assess overall protein status and kidney function.

Quick summary

["Total protein levels can signal kidney issues or nutritional concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
50499-3
Short code
GH sp7 SerPl-mCnc
Synonyms
GH sp7 SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to evaluate kidney function, detect protein-losing conditions (like nephrotic syndrome), or check for nutritional deficiencies. It’s also used in monitoring chronic diseases like liver disease or heart failure.

What Does the Result Mean?

Higher than expected levels might indicate dehydration, inflammation, or conditions like multiple myeloma. Lower levels could signal malnutrition, liver disease, or kidney problems. Results are interpreted in relation to your overall health and medical history.

Common Conditions Linked to Results

Abnormal protein levels can signal kidney disease (e.g., albuminuria), liver disorders (e.g., cirrhosis), or chronic infections. It may also help diagnose conditions like protein-losing enteropathy or certain cancers.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours if your test includes a glucose or lipid panel. Bring your medical records if you have kidney, liver, or heart conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Total protein is a key marker for diagnosing and managing conditions affecting protein synthesis, filtration, or loss. It helps guide treatment for kidney disease, liver failure, or malnutrition, ensuring your body’s protein needs are met.

Short name

Total Protein

Frequently asked questions

What causes total protein levels to be too high?
High total protein can result from dehydration, chronic inflammation, or conditions like multiple myeloma or severe infections. Kidney disease (e.g., nephrotic syndrome) may also contribute if protein is lost in urine.
What causes total protein levels to be too low?
Low total protein often signals malnutrition, liver disease (e.g., cirrhosis), or kidney problems (e.g., nephrotic syndrome). Chronic infections or certain medications may also lower protein levels.
Does diet affect total protein test results?
Yes, diet can influence protein levels. High-protein diets may raise levels temporarily, while malnutrition or low-protein diets can lower them. Your provider may ask about dietary changes if results are abnormal.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy