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Substance Concentration in Urine (Qualitative) – Specific Substances Detected (e.g., drugs, toxins, or metabolites)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of certain substances in your urine, such as drugs, alcohol, or other chemicals. It helps your healthcare provider understand if you’ve used medications, alcohol, or other substances that may affect your health.

Quick summary

["Identifies potential substance use or exposure that may require medical evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
28374-7
Short code
GIVINGUPTHINGS
Synonyms
—
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
reported-living-hiv
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

This test detects a variety of substances in your urine, including common drugs (like opioids, benzodiazepines, or cocaine), alcohol metabolites, and sometimes other chemicals or toxins. The results are qualitative, meaning they only tell you whether the substance is present or not, not how much.

How the Test Works

Your urine sample is analyzed using a method that detects specific chemical markers of substances. This could involve immunoassay or other screening techniques to identify the presence of drugs, alcohol, or other compounds without measuring exact quantities.

Why It’s Done

Doctors may order this test to assess substance use for reasons such as monitoring treatment for addiction, evaluating suspected drug abuse, or checking for exposure to harmful substances in the workplace or environment.

Possible Results and Interpretation

If the test comes back positive, it means the substance was detected in your urine. A negative result means no detectable substance was found. Always discuss the results with your healthcare provider, as they may need further testing or additional context to interpret the findings accurately.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Urine Drug Screen (Qualitative)

Frequently asked questions

Why might my doctor want to know if I’ve used substances?
Your doctor may ask about substance use to check for addiction, monitor treatment progress, screen for potential health risks, or investigate unexplained symptoms. For example, certain drugs can affect your liver, kidneys, or nervous system. If you’ve recently used substances, this test can help your provider understand your health status and guide treatment plans.
What does a positive result mean?
A positive result means the substance was found in your urine. This doesn’t always mean you’re currently using it—some substances (like alcohol) can stay in your system for days. Your doctor will discuss what this means for you based on your medical history and other test results.
Can I fast before this test?
Most urine drug screens do not require fasting. You may be asked to provide a clean-catch urine sample, so avoid urinating right before the test if instructed. Always follow your healthcare provider’s specific instructions for the best results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy