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Anti-Glomerular Basement Membrane Antibody (Anti-GBM) in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies against a protein found in the kidneys’ filtering units, helping diagnose a rare but serious condition called Goodpasture’s syndrome.

Quick summary

["This test helps identify a condition that can damage kidneys and lungs, requiring prompt medical attention."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
21302-5
Short code
G lamblia Ag sp2 Stl Ql IA
Synonyms
G lamblia Ag sp2 Stl Ql IA
Category
chemistry
Sample
stool
Container
Clean container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 g
Stability
Refrigerated: 24h, Frozen: 7d
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like blood in urine, difficulty breathing, or unexplained kidney problems. It’s particularly useful for diagnosing Goodpasture’s syndrome, an autoimmune disease where the immune system mistakenly attacks kidney tissues.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. If you’re on blood thinners, let your doctor know before the test.

What the Results Mean

Positive results (high antibody levels) strongly suggest Goodpasture’s syndrome. Negative results mean the condition is unlikely, but other causes of kidney or lung damage should still be checked.

Possible Side Effects

Most people experience mild discomfort at the needle site. Rarely, there may be bruising or swelling. If you experience severe pain or signs of infection, contact your doctor.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Anti-GBM antibodies target a protein in kidney glomeruli, leading to rapid kidney damage. Early detection through this test can guide treatment to preserve kidney function, such as steroids, plasma exchange, or immunosuppressants.

Short name

Anti-GBM Antibody

Frequently asked questions

What causes high or low antibody levels?
High levels are almost always linked to Goodpasture’s syndrome. Low or absent levels mean the condition is unlikely, but other autoimmune or infectious causes of kidney issues may still apply.
Can this test be done at home?
No, this test requires a blood sample collected by a healthcare professional in a clinical setting.
How often should this test be repeated?
Your doctor will determine the frequency based on your symptoms, treatment response, and kidney function. Follow-up tests may be needed if you’re being monitored for Goodpasture’s syndrome or related conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy