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Anti-neutrophil cytoplasmic antibody (ANCA) profile by immunoassay (serum/plasma)

Published: August 9, 2026Updated: August 17, 2026

This blood test measures antibodies that target certain proteins in white blood cells, helping identify conditions like vasculitis.

Quick summary

["This test helps diagnose autoimmune diseases affecting blood vessels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
82208-0
Short code
G lamblia DNA Stl Ql NAA+n-prb
Synonyms
G lamblia DNA Stl Ql NAA+n-prb
Category
chemistry
Sample
stool
Container
Clean container
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
non-probe-amp-tar
CPT
84484
SNOMED
302774002
Specimen volume
5 g
Stability
Refrigerated: 24h, Frozen: 7d
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like unexplained skin rashes, joint pain, kidney problems, or persistent sinus infections. It helps determine whether your symptoms could be linked to a condition called vasculitis, where inflammation damages blood vessels.

What to Expect During the Test

A small blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab for testing. You may feel slight discomfort, but it’s quick and doesn’t require special preparation.

Common Conditions Linked to ANCA Test Results

Positive results may indicate conditions such as Wegener’s granulomatosis, microscopic polyangiitis, or Churg-Strauss syndrome. These are types of vasculitis where small blood vessels become inflamed, potentially causing organ damage.

How Results Are Interpreted

Results are typically reported as positive or negative for specific ANCA types (e.g., c-ANCA or p-ANCA). Your doctor will review these with your symptoms and other test results to guide treatment.

Reference range

Adult: 10-40 U/LN/A

Specimen: stool

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: ANCA antibodies play a key role in diagnosing and guiding treatment for vasculitis. Early detection can improve outcomes by allowing targeted therapies to reduce inflammation and prevent organ damage.

Short name

ANCA Profile

Frequently asked questions

What does a positive ANCA test mean?
A positive result suggests you may have an autoimmune condition affecting blood vessels, but it doesn’t confirm the exact diagnosis. Your doctor will consider other factors, like symptoms and further tests.
Can ANCA test results change over time?
Yes, ANCA levels can fluctuate with treatment or disease activity. Regular follow-up testing may be needed to monitor changes and adjust care as needed.
Is fasting required for this test?
No fasting is required. This test is a blood draw and doesn’t depend on diet or timing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy