Serum or Plasma Glutamate Oxaloacetate Transaminase (GOT) Activity

What Does This Test Measure?

GOT (also called transaminase) is an enzyme found in your liver, heart, muscle, and other tissues. When cells are damaged—such as in liver disease or muscle injury—the enzyme leaks into the bloodstream. This test quantifies how much GOT is present in your serum or plasma.

Why Might You Need This Test?

Your healthcare provider may order this test to check for liver problems (e.g., hepatitis, cirrhosis), muscle injuries, or other conditions affecting these organs. It’s often used alongside other tests to diagnose or monitor conditions like alcohol-related liver disease or certain heart or muscle disorders.

Common Conditions Monitored

Elevated GOT levels may indicate inflammation or damage in organs like the liver, heart, or skeletal muscle. For example, high levels could signal viral hepatitis, alcohol abuse, or muscle disorders. However, GOT alone isn’t diagnostic—it’s usually part of a broader evaluation.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The blood is then separated into serum (liquid part after clotting) or plasma (liquid part after anticoagulant use) for testing. No special preparation is needed, but fasting may be advised depending on your provider’s instructions.