Gluten IgA Antibodies (Anti-Gliadin IgA)

What This Test Measures

The test detects specific antibodies (IgA) your immune system produces in response to gluten, a protein found in wheat, barley, and rye. These antibodies can signal an immune reaction that may harm the small intestine, especially in people with celiac disease or gluten sensitivity.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like persistent diarrhea, stomach pain, weight loss, or fatigue, or if you have a family history of celiac disease or gluten-related disorders. It can also be part of a diagnostic workup for unexplained digestive issues.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for a few hours before the blood draw if your lab requires it. Bring a list of medications you’re currently taking, as some may affect test results.

What the Results Mean

Positive results suggest an immune response to gluten, which may warrant further testing (like an endoscopy or genetic testing for celiac disease). Negative results mean no detectable antibodies to gluten in this sample, but they don’t rule out celiac disease entirely.