Serum Gluten Immunoglobulin G (IgG) Antibody Test
This test measures the level of Immunoglobulin G (IgG) antibodies your body produces in response to gluten, a protein found in wheat, barley, and rye.
["Helps assess potential gluten sensitivity or autoimmune reactions to gluten without requiring a strict elimination diet."]
Key facts at a glance
- LOINC
- 5170-6
- Short code
- Gliadin IgG Ser-aCnc
- Synonyms
- Gliadin IgG Ser-aCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
IgG antibodies are part of your immune system’s response to gluten. This test detects their presence in your serum, which may indicate an immune reaction to gluten, though not necessarily celiac disease or non-celiac gluten sensitivity. Levels can vary based on diet, health status, and immune response.
Why It Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like bloating, diarrhea, or fatigue that could be linked to gluten exposure, even if you don’t meet strict criteria for celiac disease or gluten sensitivity. It’s sometimes used as a screening tool before more specific testing.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to fast for a few hours before the blood draw. Wear comfortable clothing and plan to rest after the test. Avoid alcohol or strenuous activity the day of the test.
What to Expect During the Test
A healthcare professional will draw blood from a vein in your arm. You may feel a slight pinch, but it’s typically over quickly. The blood sample is then sent to a lab for analysis.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
While elevated IgG antibodies to gluten can suggest an immune response, they don’t definitively diagnose celiac disease or gluten sensitivity. Higher levels may indicate recent gluten exposure or an ongoing immune reaction. False positives can occur, so results should be interpreted by a healthcare provider alongside symptoms and other tests.
Short name
Gluten IgG Antibody (Serum)
Frequently asked questions
Can this test diagnose celiac disease?
What if my IgG antibody levels are high?
Does this test replace a gluten-free diet?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy