Gluten IgA Antibodies (Serum) – Total

Why This Test Might Be Ordered

Your doctor may recommend this screening test if you have symptoms such as persistent diarrhea, abdominal pain, fatigue, or unexplained weight loss. It may also be suggested if you have a family history of celiac disease, autoimmune disorders, or if you’ve been diagnosed with an allergy to wheat or gluten. Some people with celiac disease don’t have classic symptoms, so this test can help detect it early.

What to Expect Before the Test

No special preparation is needed for this test. You may have a blood sample drawn from a vein in your arm, usually during a routine office visit. The process is quick and typically causes only mild discomfort.

What the Test Results Mean

A positive result indicates the presence of gluten-specific IgA antibodies, which can signal celiac disease or gluten sensitivity. However, a positive result alone doesn’t confirm a diagnosis—further testing, such as an endoscopy with biopsy, may be needed. False positives can occur, so results should always be interpreted by a healthcare provider.

What Happens Next

If your test results are positive, your doctor may recommend additional testing, including a gluten-free trial to see if symptoms improve. They may also suggest genetic testing for HLA-DQ2 or HLA-DQ8 markers, which are strongly linked to celiac disease. Follow-up may include a biopsy of your small intestine to confirm the diagnosis.