Gluten-Dependent IgA Anti-Gliadin Peptide Antibody (Serum)
This test measures antibodies in your blood that react to gliadin, a protein found in gluten, a component of wheat, barley, and rye. It helps evaluate potential gluten sensitivity or celiac disease.
["This test may help identify if gluten triggers an immune response in your digestive system."]
Key facts at a glance
- LOINC
- 109392-1
- Short code
- Gliadin peptide IgA Msmt Ser
- Synonyms
- Gliadin peptide IgA Msmt Ser
- Category
- coagulation
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0.8
- Ref high
- 1.2
- Critical range
- — – 5 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85610
- SNOMED
- 396252006
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test detects IgA antibodies that target gliadin peptides—a fragment of gluten. These antibodies are often elevated in people with gluten sensitivity or celiac disease, where the immune system mistakenly attacks the small intestine.
Why It Might Be Ordered
Your doctor may recommend this test if you have symptoms like persistent diarrhea, bloating, weight loss, or fatigue, especially after eating gluten-containing foods. It can also be part of a broader evaluation for digestive issues or autoimmune conditions linked to gluten.
How the Test Works
A blood sample is taken, and the serum is analyzed using an immunoassay method to identify the presence of IgA antibodies against gliadin. This helps determine if your immune system is reacting to gluten.
What to Expect Before the Test
No special preparation is needed, but inform your doctor if you’re on medications, have recent infections, or are pregnant. Avoiding gluten for a few days before testing may not affect results but can help clarify symptoms.
Reference range
INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A
Inform your healthcare provider if you are taking blood thinners. No special preparation required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated levels of these antibodies can suggest gluten sensitivity or celiac disease, though they are not definitive proof. Positive results may prompt further testing, such as endoscopy or genetic screening for HLA-DQ2/DQ8 genes, to confirm a diagnosis. False positives can occur, so results should be interpreted by a healthcare provider in the context of symptoms and other tests.
Short name
IgA Anti-Gliadin Peptide Antibody
Frequently asked questions
What does a positive result mean?
Can I eat gluten before this test?
Are there any risks or side effects from this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy