Gluten IgA Antibodies (Anti-Gliadin IgA)
This test measures antibodies to gliadin, a protein found in gluten, which can help identify possible gluten sensitivity or celiac disease.
["Helps assess gluten-related immune responses in the digestive system."]
Key facts at a glance
- LOINC
- 58709-7
- Short code
- Gliadin peptide IgA Ser-aCnc
- Synonyms
- Gliadin peptide IgA Ser-aCnc
- Category
- coagulation
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0.8
- Ref high
- 1.2
- Critical range
- — – 5 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85610
- SNOMED
- 396252006
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test detects the presence of IgA antibodies against gliadin, a protein derived from wheat, barley, and rye. These antibodies are part of the body’s immune response when gluten is consumed. Elevated levels may suggest an immune reaction to gluten, which can be linked to conditions like celiac disease or non-celiac gluten sensitivity.
Why It Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like persistent digestive issues (e.g., bloating, diarrhea), unexplained weight changes, fatigue, or if you have a family history of gluten-related disorders. It can also be part of a broader evaluation for autoimmune conditions or unexplained gastrointestinal problems.
What to Expect Before the Test
No special preparation is typically needed, but you may be asked to fast for a few hours before the blood draw. Wear comfortable clothing and plan for the test to be done at a clinic or lab. Bring any medications or relevant medical records if instructed.
What to Expect During the Test
A healthcare professional will collect a small blood sample from a vein in your arm. The process is quick and usually painless, though you may feel a slight pinch. The sample is then sent to a lab for analysis.
Reference range
INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A
Inform your healthcare provider if you are taking blood thinners. No special preparation required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated levels of anti-gliadin IgA antibodies may indicate an immune response to gluten, which can be associated with celiac disease (an autoimmune condition where gluten damages the small intestine) or non-celiac gluten sensitivity. However, these antibodies are not definitive for celiac disease alone; other tests (such as endoscopy or genetic testing) may be needed for a full diagnosis. Always discuss results with your doctor, as they will interpret the findings in the context of your symptoms and medical history.
Short name
Gluten IgA Antibody Test
Frequently asked questions
How long does it take to get results?
Can I eat gluten before the test?
Are there any risks or side effects from this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy