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Serum IgA Anti-Gliadin Antibodies (Peptide-Specific)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies in your blood that react to gliadin, a protein found in gluten. It helps evaluate potential gluten sensitivity or celiac disease.

Quick summary

This test checks for gluten-related immune responses that may indicate digestive or health concerns.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63453-5
Short code
Gliadin peptide IgA Ser IA-aCnc
Synonyms
Gliadin peptide IgA Ser IA-aCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like persistent diarrhea, stomach pain, weight loss, or fatigue. It’s also used in the evaluation of celiac disease, gluten sensitivity, or unexplained gastrointestinal issues.

What to Expect During the Test

A blood sample is taken from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause pain. The test itself is quick and done in a lab.

What the Results Mean

Positive results suggest an immune response to gluten, which can help guide dietary or medical decisions. However, results alone don’t diagnose celiac disease—additional testing may be needed.

Common Symptoms Linked to Positive Results

Symptoms like bloating, nausea, or digestive discomfort may appear if gluten triggers an immune reaction. Some people experience no symptoms but still have elevated antibody levels.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: serum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test plays a role in diagnosing gluten-related disorders by identifying antibodies that attack gluten proteins. While not definitive for celiac disease, it supports further evaluation with other tests (like endoscopy or genetic screening).

Short name

IgA Anti-Gliadin Antibody Test

Frequently asked questions

What triggers this test?
Your doctor may order it if you have symptoms like chronic diarrhea, unexplained weight loss, or a family history of celiac disease. It’s sometimes used as part of a gluten-related disorder screening.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab. Your provider will discuss them with you during your follow-up visit.
Can I eat gluten before the test?
Yes, you can eat your usual diet before testing, as this test measures your natural immune response to gluten. Avoiding gluten temporarily may not be necessary unless your doctor advises it.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy