IgG Antibodies to Gliadin Peptide (Serum)

What Does This Test Measure?

Gliadin is a protein in gluten that your digestive system may break down. If your immune system reacts to gliadin, it may produce antibodies like IgG. This test detects these antibodies in your blood, specifically targeting gliadin peptides. Elevated levels might suggest an immune response to gluten, though they don’t always indicate celiac disease alone.

Why Might You Need This Test?

Doctors may recommend this test if you have symptoms like bloating, diarrhea, or fatigue that don’t improve with a gluten-free diet. It can also be part of an evaluation for gluten-related disorders, though other tests (like endoscopy or genetic testing) may be needed for a full diagnosis.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to avoid certain medications (like steroids) that could affect results. If you’re on a gluten-free diet, your doctor may advise temporarily reintroducing gluten to assess symptoms before testing.

What Are Possible Results?

Results are qualitative (positive or negative) rather than numeric. A positive test means your body detected gliadin antibodies, but it doesn’t confirm celiac disease or gluten intolerance alone. Follow-up testing or a gluten challenge may be needed for further evaluation.