Serum IgG to Gluten-Dependent Peptide Antibodies (Total)
This test measures the level of antibodies your immune system produces in response to gluten peptides, which are proteins found in wheat, barley, and rye. It helps identify potential celiac disease or gluten sensitivity.
["This test helps doctors check for an immune reaction to gluten that may indicate celiac disease or gluten-related disorders."]
Key facts at a glance
- LOINC
- 58710-5
- Short code
- Gliadin peptide IgG Ser-aCnc
- Synonyms
- Gliadin peptide IgG Ser-aCnc
- Category
- coagulation
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0.8
- Ref high
- 1.2
- Critical range
- — – 5 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85610
- SNOMED
- 396252006
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your healthcare provider may order this test if you have symptoms like stomach pain, diarrhea, weight loss, fatigue, or unexplained nutritional deficiencies. It may also be used as part of a screening process for celiac disease, especially if you have a family history of the condition or symptoms that match celiac disease criteria.
What to Expect Before the Test
No special preparation is usually needed. You may be asked to fast for a few hours before the blood draw, but this is not always required. If you are on a gluten-free diet, your doctor may advise you to restart eating gluten for a period before testing to ensure accurate results.
What the Test Involves
A healthcare professional will draw blood from a vein in your arm. This is a simple procedure that usually takes a few minutes. You may feel a slight pinch or discomfort, but it is generally well-tolerated.
What the Results Mean
Results are not provided as a single numeric range, as they depend on the specific antibody levels and clinical context. Elevated levels may suggest an immune response to gluten, which could be linked to celiac disease or gluten sensitivity. Your doctor will interpret the results in relation to your symptoms and medical history.
Reference range
INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A
Inform your healthcare provider if you are taking blood thinners. No special preparation required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated IgG anti-gliadin antibodies can indicate an ongoing immune reaction to gluten, which is a hallmark of celiac disease. While IgG antibodies are not as specific as IgA antibodies for diagnosing celiac disease, they can be part of a broader diagnostic workup. Persistently high levels combined with other symptoms and positive tests for tissue transglutaminase antibodies (tTG) or endomysial antibodies may support a diagnosis of celiac disease. Gluten sensitivity or non-celiac gluten disorder may also be considered if symptoms are present but tests are negative.
Short name
IgG Anti-Gliadin Antibody Test
Frequently asked questions
How long does it take to get my test results?
Can I eat gluten before this test?
What are the common symptoms that might lead to this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy