IgG to Gluten (Gliadin) Antibodies, Serum
This blood test measures your immune system’s response to gluten, a protein found in wheat, barley, and rye. It helps identify potential celiac disease or gluten sensitivity.
["This test checks if gluten triggers an immune reaction in your body."]
Key facts at a glance
- LOINC
- 47394-2
- Short code
- Gliadin peptide IgG Ser Ql IA
- Synonyms
- Gliadin peptide IgG Ser Ql IA
- Category
- coagulation
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0.8
- Ref high
- 1.2
- Critical range
- — – 5 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ia
- CPT
- 85610
- SNOMED
- 396252006
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your doctor may recommend this test if you have symptoms like stomach pain, diarrhea, fatigue, or unexplained weight loss. It’s also used to screen for celiac disease or gluten-related disorders when other tests are inconclusive.
What to Expect Before the Test
No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re on blood thinners, let your doctor know before the test.
What the Results Mean
High levels of these antibodies suggest an immune response to gluten, which could indicate celiac disease or gluten sensitivity. However, results alone don’t diagnose the condition—your doctor will review them with your symptoms and other tests.
Common Symptoms Linked to High Antibody Levels
Symptoms like bloating, chronic diarrhea, joint pain, or anemia may appear if gluten triggers an immune reaction. Some people have no symptoms but still test positive.
Reference range
INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A
Inform your healthcare provider if you are taking blood thinners. No special preparation required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated gluten-specific IgG antibodies can signal an ongoing immune response to gluten, supporting a diagnosis of celiac disease or gluten sensitivity. While IgG tests aren’t definitive, they’re useful for screening. If positive, further testing (like endoscopy or genetic screening) may be needed to confirm celiac disease. Gluten avoidance is the primary treatment for celiac disease, and monitoring antibody levels over time can help track response to diet changes.
Short name
Gluten-Specific IgG Antibody Test
Frequently asked questions
What Does a Positive Test Mean?
Can This Test Be Used to Diagnose Celiac Disease?
How Often Should I Get This Test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy