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Gluten-Dependent IgA Anti-Gliadin Peptide Antibody (IgA Anti-Gliadin Peptide Antibody)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies to specific peptides in gluten, a protein found in wheat, barley, and rye. It helps identify possible gluten sensitivity or celiac disease.

Quick summary

This test may help diagnose gluten-related conditions by detecting immune responses to gluten proteins.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63420-4
Short code
Gliadin peptide+tTG IgA+IgG Ser Ql IA
Synonyms
Gliadin peptide+tTG IgA+IgG Ser Ql IA
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like digestive issues, fatigue, or unexplained weight changes. It’s often used alongside other tests to check for gluten-related disorders, such as celiac disease or non-celiac gluten sensitivity.

What the Test Measures

The test looks for IgA antibodies that target specific fragments of gluten proteins. These antibodies are part of your immune system’s response to gluten, which can occur in people with gluten sensitivity or celiac disease.

How the Test Works

A small blood sample is taken, usually from your arm. The sample is then analyzed in a lab to detect the presence of these antibodies. The results help determine if your body is reacting to gluten in a way that may cause health issues.

What the Results Mean

High levels of these antibodies may suggest a gluten-related condition, but they are not definitive on their own. Your doctor will consider your symptoms, medical history, and possibly other tests to make a diagnosis.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: serum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

IgA Anti-Gliadin Peptide Antibody

Frequently asked questions

What does a positive result mean?
A positive result indicates your immune system is reacting to gluten peptides, which may point toward gluten sensitivity or celiac disease. However, false positives can occur, so further testing and evaluation are needed to confirm a diagnosis.
How often should I get this test?
This test may be repeated if your symptoms change or if your doctor suspects a recurrence of gluten-related issues. It’s also sometimes used as part of ongoing monitoring for celiac disease.
Can I eat gluten before the test?
Yes, you can eat a normal diet before the test, as the antibodies are part of your body’s natural response to gluten. However, if you’re being tested for celiac disease, your doctor may advise avoiding gluten for a few weeks before testing to get more accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy