Serum Protein Electrophoresis (Fractionated)
This test measures the different types of proteins in your blood, separated by size and charge, to help identify abnormalities in protein distribution.
["This test helps diagnose conditions like multiple myeloma, liver disease, or kidney problems by checking protein patterns in your blood."]
Key facts at a glance
- LOINC
- 14341-2
- Short code
- Globulin 24h MFr Ur Elph
- Synonyms
- Globulin 24h MFr Ur Elph
- Category
- chemistry
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Ref low
- 7.35
- Ref high
- 7.45
- Critical range
- 7.2 N/A – 7.6 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- electrophoresis
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What Proteins Are Measured?
Electrophoresis separates proteins into distinct bands based on their electrical charge and molecular weight. Key fractions include albumin, alpha-globulins, beta-globulins, and gamma-globulins. Each band reflects the concentration of specific proteins, which can indicate underlying health issues.
Why Is This Test Done?
Doctors may order this test to investigate symptoms like fatigue, swelling, or unexplained weight changes. It’s also used to monitor conditions like chronic kidney disease, infections, or cancers that affect protein levels.
Sample Preparation and Testing Process
A blood sample is drawn, and serum is separated for analysis. The serum is applied to a gel and placed in an electric field, causing proteins to migrate toward the opposite charge. After separation, bands are visualized and measured.
What Does the Result Mean?
Results show the relative amounts of each protein band. Abnormal patterns (e.g., sharp peaks in gamma-globulins or low albumin) may signal conditions like monoclonal gammopathy, liver dysfunction, or malnutrition.
Reference range
NCBI: pH 7.35-7.45N/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Protein Electrophoresis
Frequently asked questions
Abnormal protein electrophoresis can reveal hidden health issues, such as monoclonal gammopathies (e.g., multiple myeloma), immune disorders, or metabolic diseases. Early detection may guide treatment decisions.
How long does it take to get results?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy