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Serum Protein Electrophoresis (Globulin Fraction)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood, focusing on the globulin portion, which includes antibodies and other proteins that help fight infection and support immune function.

Quick summary

["Globulins help your body defend against illness and maintain fluid balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14430-3
Short code
Globulin Snv-mCnc
Synonyms
Globulin Snv-mCnc
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test to evaluate immune function, detect abnormalities in protein levels, or investigate symptoms like fatigue, swelling, or unexplained infections. It can also help diagnose conditions such as multiple myeloma, lymphoma, or chronic inflammatory diseases.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm. The test is quick and typically done in a lab setting.

What the Results Mean

The results show the proportion of globulins relative to other proteins (albumin, globulins, and total protein). Abnormal patterns may indicate immune disorders, infections, or other health issues.

Common Conditions Linked to Abnormal Globulin Levels

High globulin levels might suggest chronic infections, autoimmune diseases, or certain cancers. Low levels could indicate malnutrition, liver disease, or kidney problems.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Globulins (Serum Protein Electrophoresis)

Frequently asked questions

What causes globulin levels to change?
Globulin levels can change due to infections, autoimmune diseases, cancers (like lymphoma or multiple myeloma), liver or kidney disease, or certain medications. Lifestyle factors like diet and stress may also play a role.
How long does it take to get results?
Results are usually available within 1 to 3 business days, depending on your lab’s processing time. Follow-up with your doctor if you have questions or concerns about your results.
Can diet affect globulin test results?
Dietary changes alone won’t alter globulin levels significantly, but certain foods high in protein or vitamins (like fish, nuts, or leafy greens) may influence overall protein balance indirectly. Avoid extreme dietary restrictions before testing unless instructed by your doctor.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy