Skip to content

Serum or plasma globulin concentration (mass concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of globulin proteins in your blood. Globulins are a group of proteins that help with immune function, blood clotting, and transporting substances in your body.

Quick summary

["Globulins support immunity and blood health—abnormal levels may signal underlying conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
18320-2
Short code
Globulin Ur Calc-mCnc
Synonyms
Globulin Ur Calc-mCnc
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
calculated
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Globulins Do in Your Body

Globulins are part of your blood’s protein family, including antibodies (which fight infections), clotting factors (to prevent bleeding), and transport proteins (like those carrying iron or lipids). They help your immune system respond to pathogens and maintain overall blood health.

How the Test Works

Your blood sample is analyzed to quantify globulin proteins. The test may use methods like nephelometry or immunoturbidimetry to measure their mass concentration in your serum or plasma.

Possible Causes of Abnormal Results

Low globulin levels may occur with chronic liver disease, malnutrition, or certain immune disorders. High levels could be linked to chronic infections, autoimmune diseases, or conditions like multiple myeloma.

When This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like fatigue, frequent infections, or unexplained swelling. It’s also part of routine evaluations for conditions affecting protein balance, such as kidney disease or liver disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Globulin Level

Frequently asked questions

Why might my globulin test result be different from what I expected?
Results can vary based on your overall health, diet, and medical conditions. For example, infections or liver/kidney problems may temporarily alter globulin levels. Always discuss your results with your healthcare provider.
Could diet affect my globulin test?
Yes, protein-rich foods (like lean meats, eggs, or dairy) can influence globulin levels. Severe malnutrition may lower them, while certain medications (e.g., steroids) might raise them. Your provider may ask about your diet if results seem unusual.
What if my globulin test is out of reference range?
If your result is outside normal limits, your doctor will likely review your medical history, symptoms, and other tests to determine the cause. Conditions like chronic inflammation, infections, or protein-losing syndromes may be investigated further.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy