Skip to content

Glucose, Serum or Plasma (High-Performance Liquid Chromatography)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of glucose, a type of sugar, in your blood. Glucose is your body’s main source of energy.

Quick summary

["Check your blood sugar levels to manage energy and prevent complications from high or low blood sugar."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
40182-8
Short code
Glucose 16h p chal SerPl-sCnc
Synonyms
Glucose 16h p chal SerPl-sCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
70
Ref high
100
Critical range
50 N/A – 400 N/A
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
CPT
82947
SNOMED
260395008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for diabetes, monitor blood sugar levels in people with diabetes, or evaluate conditions affecting metabolism, such as liver or kidney disease. It can also help diagnose hypoglycemia (low blood sugar) or hyperglycemia (high blood sugar).

What Does the Test Involve?

A small amount of blood is drawn from a vein, usually in your arm. The blood sample is then sent to a lab for analysis using high-performance liquid chromatography (HPLC), which separates and measures glucose levels accurately.

What to Expect Before the Test

No special preparation is needed for this test. However, if you are diabetic, you may be asked to fast before the test to get a more accurate reading. Always follow your healthcare provider’s instructions for any specific preparations.

What to Expect During the Test

You will sit comfortably while a healthcare professional inserts a small needle into your arm to collect blood. The process usually takes a few minutes. You may feel a slight pinch or discomfort, but it is generally quick and painless.

Reference range

Fasting: 70-100 mg/dLN/A

Specimen: serum

Fasting for 8-12 hours required. Water is permitted. Avoid chewing gum and smoking before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal glucose levels can indicate diabetes, prediabetes, or other metabolic disorders. High glucose levels over time can damage blood vessels and nerves, increasing the risk of heart disease, nerve damage, kidney problems, and vision issues. Low glucose levels can cause dizziness, confusion, or fainting. Regular monitoring helps manage these conditions effectively.

Short name

Glucose Level

Frequently asked questions

How often should I get this test?
The frequency depends on your health status. People without diabetes may get this test occasionally as part of a routine checkup. Those with diabetes usually get it more regularly, often every few months or as directed by their doctor.
What are the possible risks or side effects?
The most common side effect is a slight bruise, redness, or soreness at the injection site. Rarely, there may be a slight swelling or infection. If you experience severe pain, excessive bleeding, or signs of infection (like fever or increased redness), contact your healthcare provider.
Can I eat or drink before this test?
For a fasting test, you should not eat or drink anything except water for 8 to 12 hours before the test. If it’s a non-fasting test, you can eat and drink normally unless instructed otherwise by your healthcare provider.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy