Skip to content

Glucose, measured by high-performance liquid chromatography (HPLC) in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of glucose (sugar) in your blood, using a precise HPLC method. It helps assess how well your body is managing blood sugar levels.

Quick summary

["This test helps monitor blood sugar control, often used alongside other glucose tests for detailed evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
1501-6
Short code
Glucose 1h p 100 g Glc PO SerPl-mCnc
Synonyms
Glucose 1h p 100 g Glc PO SerPl-mCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
70
Ref high
100
Critical range
50 N/A – 400 N/A
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
CPT
82947
SNOMED
260395008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for diabetes, prediabetes, or to monitor blood sugar levels in people with known diabetes. It can also help diagnose conditions like hypoglycemia (low blood sugar) or other metabolic disorders.

How Is the Sample Collected?

A small amount of blood will be drawn from a vein, usually in your arm, by a healthcare professional. The blood sample is then processed to separate serum or plasma for testing.

What Should You Expect Before the Test?

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a fasting glucose profile. If you’re unsure, ask your provider for specific instructions.

What Are Common Results and Their Meanings?

Results are typically reported as a mass concentration of glucose in the blood. While reference ranges can vary by lab, higher or lower than expected levels may signal potential health concerns that need further evaluation.

Reference range

Fasting: 70-100 mg/dLN/A

Specimen: serum

Fasting for 8-12 hours required. Water is permitted. Avoid chewing gum and smoking before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test plays a critical role in diagnosing and managing blood sugar disorders. High glucose levels may indicate diabetes or insulin resistance, while persistently low levels could signal hypoglycemia or other metabolic issues. Regular monitoring helps prevent complications like nerve damage, kidney problems, or heart disease.

Short name

Glucose Level (HPLC)

Frequently asked questions

What does a high glucose level mean?
A high glucose level may suggest diabetes or insulin resistance. Your provider will discuss next steps, such as lifestyle changes, medication, or further testing to manage your condition.
How often should I get this test?
Frequency depends on your health status. People with diabetes may need this test monthly or more often, while others may only need it periodically as advised by their healthcare provider.
Can diet or exercise affect my glucose test results?
Yes, fasting before the test is often required. If you’ve eaten or exercised recently, it may impact results. Follow your provider’s instructions to ensure accurate testing.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy