Skip to content

Glucose, Serum or Plasma (High-Pressure Liquid Chromatography)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of glucose (sugar) in your blood, drawn from either serum or plasma. Glucose levels help assess how your body uses energy and can indicate risks for conditions like diabetes.

Quick summary

["Glucose levels reflect your body’s ability to process energy and may signal diabetes or other metabolic concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
1504-0
Short code
Glucose 1h p 50 g Glc PO SerPl-mCnc
Synonyms
Glucose 1h p 50 g Glc PO SerPl-mCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
70
Ref high
100
Critical range
50 N/A – 400 N/A
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
CPT
82947
SNOMED
260395008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for diabetes, monitor blood sugar control in people with diabetes, diagnose or manage conditions like hypoglycemia (low blood sugar), or evaluate metabolic health. It can also help assess how well medications are working for blood sugar management.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast (not eat or drink) for 8–12 hours before the test if it’s part of a fasting glucose study. If you’re not fasting, you can eat and drink normally. Let your provider know about any medications you’re taking, as some may affect results.

During the Test

A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a brief pinch, but the process is quick. The blood sample is then sent to a lab for analysis using high-performance liquid chromatography (HPLC), which separates and measures glucose with high precision.

What the Results Mean

Results are typically reported in milligrams per deciliter (mg/dL) or millimoles per liter (mmol/L). While reference ranges vary by lab, lower or higher-than-normal levels may signal potential health issues that need further evaluation by your doctor.

Reference range

Fasting: 70-100 mg/dLN/A

Specimen: serum

Fasting for 8-12 hours required. Water is permitted. Avoid chewing gum and smoking before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated glucose levels may indicate diabetes, prediabetes, or insulin resistance. Persistently low levels can cause fatigue, dizziness, or confusion. Regular monitoring helps prevent complications like nerve damage, kidney disease, or heart problems. Your provider will discuss results in the context of your overall health and treatment plan.

Short name

Glucose Level

Frequently asked questions

What causes glucose levels to change?
Several factors can influence glucose levels, including diet (especially sugary foods or drinks), physical activity, stress, certain medications (like steroids or birth control), illness, or hormonal changes. If you notice sudden changes, talk to your doctor about possible triggers.
How often should I get this test?
Frequency depends on your health status. People without diabetes may get a routine glucose test every few years, while those with diabetes typically check levels monthly or more often as advised by their healthcare provider. Follow-up tests help track progress with treatment.
Can lifestyle changes affect my glucose test results?
Yes! Eating balanced meals, staying physically active, managing stress, and avoiding excessive sugar can help stabilize blood sugar levels. If you’ve made recent lifestyle changes, discuss them with your provider to ensure accurate results and personalized advice.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy