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Serum Glucose (High-Performance Liquid Chromatography Method)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of glucose (sugar) in your blood serum. Glucose is a key energy source for your body.

Quick summary

["Your blood sugar levels help manage energy and can signal health risks if too high or too low."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14756-1
Short code
Glucose 1h p Glc SerPl-sCnc
Synonyms
Glucose 1h p Glc SerPl-sCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
70
Ref high
100
Critical range
50 N/A – 400 N/A
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
CPT
82947
SNOMED
260395008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to check for diabetes, monitor blood sugar levels, assess metabolic health, or evaluate symptoms like excessive thirst, fatigue, or unexplained weight changes.

What to Expect Before the Test

No special preparation is needed. You may fast for 8–12 hours before the test if instructed, but this is not always required. Bring any medications you’re taking to your appointment.

How the Test Works

A blood sample is taken from a vein, usually in your arm. The sample is sent to a lab where glucose levels are measured using high-performance liquid chromatography (HPLC), a precise method for detecting sugar concentration.

What the Results Mean

Results help determine if your blood sugar is within normal ranges or if further action is needed. Abnormal results may prompt additional testing or lifestyle recommendations.

Reference range

Fasting: 70-100 mg/dLN/A

Specimen: serum

Fasting for 8-12 hours required. Water is permitted. Avoid chewing gum and smoking before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Glucose Level

Frequently asked questions

How often should I get this test?
Your doctor will decide how often you need this test based on your health history, symptoms, and treatment plan. Regular check-ups may include this test every few months or annually.
What does a ‘high’ or ‘low’ glucose result mean?
A ‘high’ result may signal diabetes or insulin resistance, while a ‘low’ result could indicate hypoglycemia (low blood sugar). Your doctor will discuss results with you and explain what actions, if any, are needed.
Can I eat or drink before this test?
Some tests require fasting, but this glucose test often does not. Always follow your doctor’s instructions, as fasting may not apply here but could affect other tests.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy