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Glucose (Serum or Plasma) by High-Performance Liquid Chromatography (HPLC)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of glucose (sugar) in your blood, typically drawn from a vein or collected in a tube from your arm.

Quick summary

["Glucose levels help monitor blood sugar and identify conditions like diabetes or metabolic issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
40219-8
Short code
Glucose 30H p chal SerPl-sCnc
Synonyms
Glucose 30H p chal SerPl-sCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
70
Ref high
100
Critical range
50 N/A – 400 N/A
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
CPT
82947
SNOMED
260395008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for high or low blood sugar levels, diagnose diabetes, evaluate how your body processes glucose, or monitor treatment for conditions like diabetes or liver disease. It can also help assess metabolic disorders or check for signs of dehydration or stress.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast (not eat or drink) for 8–12 hours before the test if it’s part of a fasting glucose study. If drawn from a vein, you’ll have a small needle inserted into your arm for a few minutes.

What Happens During the Test?

A healthcare professional will collect a blood sample from a vein in your arm using a needle. The sample is then sent to a lab for analysis using high-performance liquid chromatography (HPLC), a precise method to measure glucose concentration.

What to Expect After the Test

You may feel slight bruising or discomfort at the injection site, but this usually fades quickly. You can resume normal activities immediately unless your provider gave other instructions.

Reference range

Fasting: 70-100 mg/dLN/A

Specimen: serum

Fasting for 8-12 hours required. Water is permitted. Avoid chewing gum and smoking before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

High glucose levels may indicate diabetes, prediabetes, or other metabolic disorders, while persistently low levels could signal hypoglycemia (dangerously low blood sugar), adrenal insufficiency, or other conditions. Regular monitoring helps manage these conditions effectively and prevent complications.

Short name

Glucose Level

Frequently asked questions

How long does it take to get results?
Results are typically available within 1–2 business days, depending on your lab’s processing time. Your provider will contact you once they’re ready to discuss the results.
What does a normal range mean?
A normal glucose level is generally considered below 100 mg/dL when fasting, though ranges can vary by lab and test type. Your provider will interpret results in the context of your overall health and medical history.
Can I eat or drink before this test?
If fasting is required, avoid food and liquids (except water) for 8–12 hours before testing. If not fasting, you can eat normally, but check with your provider to confirm.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy