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Serum Glucose Concentration (High-Performance Liquid Chromatography Method)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of glucose (sugar) in your blood serum using a high-performance liquid chromatography method. Glucose is a key energy source for your body.

Quick summary

["This test helps monitor blood sugar levels, often used in diabetes management or metabolic assessments."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
9376-5
Short code
Glucose 3.5h p 100 g Glc PO SerPl-mCnc
Synonyms
Glucose 3.5h p 100 g Glc PO SerPl-mCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
70
Ref high
100
Critical range
50 N/A – 400 N/A
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
CPT
82947
SNOMED
260395008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like diabetes, hypoglycemia (low blood sugar), or to assess how your body processes glucose. It can also be used during pregnancy, before surgeries, or to evaluate metabolic disorders.

What Does the Result Mean?

Results are typically reported as a mass concentration of glucose in milligrams per deciliter (mg/dL). While reference ranges vary by lab, higher or lower than expected levels may signal potential health concerns that need further evaluation.

How Is This Test Performed?

A blood sample is drawn from a vein, usually in your arm. The serum portion is separated and sent to the lab for glucose measurement using advanced chromatography techniques to ensure accuracy.

Preparation and Considerations

No special preparation is needed, but fasting may be required depending on the clinical context (e.g., diabetes screening). Avoiding alcohol or strenuous activity before the test can help ensure reliable results.

Reference range

Fasting: 70-100 mg/dLN/A

Specimen: serum

Fasting for 8-12 hours required. Water is permitted. Avoid chewing gum and smoking before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormally high glucose levels may indicate diabetes, poor insulin function, or other metabolic issues. Low glucose levels can cause symptoms like dizziness, confusion, or fatigue. Repeated testing and follow-up with your healthcare provider are essential for diagnosis and management.

Short name

Serum Glucose

Frequently asked questions

What causes abnormal glucose levels?
Abnormal glucose levels can result from conditions like diabetes (high levels), untreated hypoglycemia (low levels), stress, infections, or certain medications. Lifestyle factors, such as diet and physical activity, also play a role.
How often should I get this test?
Frequency depends on your health status. For people with diabetes, tests may be done monthly or more often to monitor blood sugar trends. Your healthcare provider will determine the best schedule for you.
Can diet or exercise affect this test result?
Yes, diet (especially carbohydrate intake) and exercise can impact blood glucose levels. Fasting before testing is often recommended, but your provider will guide you based on your specific situation.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy