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Glucose, Serum (High-Performance Liquid Chromatography)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of glucose, a type of sugar, in your blood serum. Glucose is your body’s main source of energy.

Quick summary

["Glucose levels help doctors check how well your body is using food for energy and managing conditions like diabetes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
20437-0
Short code
Glucose 3h p Glc SerPl-mCnc
Synonyms
Glucose 3h p Glc SerPl-mCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
70
Ref high
100
Critical range
50 N/A – 400 N/A
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
CPT
82947
SNOMED
260395008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may request this test to monitor blood sugar levels, diagnose conditions like diabetes, or assess how your body responds to treatments. It can also help check for metabolic issues or detect signs of high blood sugar, such as during pregnancy or after eating certain foods.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into your arm to draw a blood sample. If fasting is required (e.g., for certain glucose-related tests), your provider will let you know in advance. Avoid eating or drinking anything except water for 8–12 hours before the test if instructed.

What Happens During the Test

A healthcare professional will clean your arm with an antiseptic and insert a small needle to collect blood from a vein. The blood sample is then sent to a lab for analysis using high-performance liquid chromatography (HPLC), a precise method to measure glucose concentration accurately.

What the Results Mean

Results are typically reported in milligrams per deciliter (mg/dL) or millimoles per liter (mmol/L). While exact ranges vary by lab and clinical context, abnormal results may signal low or high blood sugar levels, which can affect how your body processes energy or indicate underlying health concerns.

Reference range

Fasting: 70-100 mg/dLN/A

Specimen: serum

Fasting for 8-12 hours required. Water is permitted. Avoid chewing gum and smoking before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Glucose Level

Frequently asked questions

What Does a High or Low Glucose Level Indicate?
High glucose levels may indicate diabetes, insulin resistance, or other metabolic disorders. Low levels can signal hypoglycemia (dangerously low blood sugar), which may cause dizziness, shakiness, or confusion. Regular monitoring helps manage these conditions effectively.
How Does This Test Relate to Diabetes?
Glucose tests are critical for diagnosing and managing diabetes. Chronic high glucose levels can damage blood vessels and organs over time, so consistent monitoring helps prevent complications like nerve damage or heart disease.
Can This Test Detect Prediabetes?
Yes, this test can help identify prediabetes if your glucose levels are consistently higher than normal but not yet diabetic. Early detection allows for lifestyle changes or medication to prevent progression to full-blown diabetes.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy