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Glucose in Serum or Plasma (High-Performance Liquid Chromatography)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of glucose (sugar) in your blood, using a specialized method to ensure accuracy. Glucose is a key energy source for your body.

Quick summary

["Knowing your glucose levels helps manage energy, detect diabetes, or monitor treatment."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14765-2
Short code
Glucose 3h p Glc SerPl-sCnc
Synonyms
Glucose 3h p Glc SerPl-sCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
70
Ref high
100
Critical range
50 N/A – 400 N/A
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
CPT
82947
SNOMED
260395008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters for Your Health

Glucose is the primary fuel your body uses for energy. Your brain, muscles, and organs rely on it to function properly. High or low glucose levels can lead to serious health issues, like diabetes or hypoglycemia. This test helps doctors track how well your body processes glucose, especially if you have conditions like diabetes or are taking medications that affect blood sugar.

How the Test Works

A small blood sample is taken from your arm, usually by a healthcare professional. The sample is then processed using high-performance liquid chromatography (HPLC), a precise method that separates and measures glucose levels accurately. This method is often used for detailed or specialized glucose testing, such as in research or advanced diagnostic settings.

What to Expect Before the Test

You may be asked to fast (not eat or drink anything except water) for a few hours before the test, depending on the reason for testing. If you’re not fasting, you might be asked to avoid sugary foods or drinks. Always follow your healthcare provider’s instructions. If you’re pregnant, have diabetes, or take certain medications, let your doctor know beforehand.

What to Expect During the Test

The test is quick and usually done in a doctor’s office, clinic, or lab. A healthcare professional will clean your arm with an antiseptic, insert a small needle to draw blood, and collect the sample into a tube. You may feel a slight pinch, but it’s over quickly. The blood is then sent to a lab for analysis.

Reference range

Fasting: 70-100 mg/dLN/A

Specimen: serum

Fasting for 8-12 hours required. Water is permitted. Avoid chewing gum and smoking before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Glucose Level

Frequently asked questions

What does my glucose level mean?
Your results will show the concentration of glucose in your blood. While specific reference ranges can vary by lab, high or low glucose levels may indicate conditions like diabetes, hypoglycemia, or other metabolic issues. Your doctor will interpret the results in the context of your overall health and medical history to determine if further action is needed.
Will I need to do anything special after the test?
You can usually return to your normal activities right after the test. If you had a fasting requirement, you may be able to eat or drink normally once the test is complete, but always follow your doctor’s instructions. If you experience any unusual pain, swelling, or signs of infection at the injection site, contact your healthcare provider.
How often will I need this test?
The frequency of glucose testing depends on your health condition. People without diabetes may only need occasional glucose checks, while those with diabetes or prediabetes may need tests more regularly, such as every few months or annually. Your doctor will schedule tests based on your needs and medical advice.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy