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Glucose in Plasma (Fasting, 50-Gram Oral Glucose Tolerance Test)

Published: August 9, 2026Updated: August 16, 2026

This test measures your blood sugar level after drinking a sugary drink. It helps check how your body handles glucose, which is important for managing blood sugar control.

Quick summary

["Assesses how your body responds to glucose, useful for diabetes screening and management."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
20441-2
Short code
Glucose p 50 g Glc SerPl-mCnc
Synonyms
Glucose p 50 g Glc SerPl-mCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
70
Ref high
100
Critical range
50 N/A – 400 N/A
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
CPT
82947
SNOMED
260395008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is This Test For?

A 50-gram oral glucose tolerance test involves drinking a sweet liquid containing 50 grams of glucose. Your blood sugar is then measured at specific times—typically before drinking and 1 hour after—to evaluate how your body processes glucose. This test is often used to screen for conditions like diabetes or gestational diabetes.

When Might You Need This Test?

You may need this test if you have symptoms of high blood sugar (e.g., frequent urination, excessive thirst) or if your doctor suspects prediabetes, diabetes, or gestational diabetes. It’s also sometimes used during pregnancy or if you have risk factors like obesity, a family history of diabetes, or high blood pressure.

How Is the Test Performed?

Before the test, you’ll fast for 8–12 hours. After drinking the glucose solution, your blood is drawn at set intervals (usually 1 hour post-drink) to check blood sugar levels. The test is quick but requires careful preparation to ensure accurate results.

What Are the Results Used For?

Results help determine if your body has trouble processing glucose, which can indicate diabetes or prediabetes. High levels may signal impaired glucose tolerance, while consistently low levels (if fasting) could warrant further evaluation.

Reference range

Fasting: 70-100 mg/dLN/A

Specimen: serum

Fasting for 8-12 hours required. Water is permitted. Avoid chewing gum and smoking before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: This test is critical for diagnosing glucose intolerance, a precursor to type 2 diabetes. Abnormal results may prompt additional testing, lifestyle changes, or medication to manage blood sugar levels effectively.

Short name

50g Oral Glucose Tolerance Test Glucose

Frequently asked questions

Why did my doctor order this test?
Your doctor may have recommended it to check for diabetes, prediabetes, or gestational diabetes—especially if you have symptoms like excessive thirst, frequent urination, or risk factors like obesity, high blood pressure, or a family history of diabetes.
What should I do before the test?
Follow your doctor’s instructions carefully: fast for 8–12 hours before drinking the glucose solution, avoid caffeine or sugary foods, and stay hydrated (but no water before the drink). Bring any medications you’re taking with you.
Will the test hurt?
No, the blood draw is quick and may cause mild discomfort. You’ll likely feel fine afterward, but if you experience dizziness or lightheadedness, let your doctor know.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy