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Glucose, Plasma (High-Performance Liquid Chromatography)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of glucose (sugar) in your plasma, a component of blood. It helps assess how well your body is using sugar for energy.

Quick summary

["This test checks your blood sugar levels in plasma for diabetes management or metabolic health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16914-4
Short code
Glucose p chal SerPl-mCnc
Synonyms
Glucose p chal SerPl-mCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
70
Ref high
100
Critical range
50 N/A – 400 N/A
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
CPT
82947
SNOMED
260395008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to monitor blood sugar levels in people with diabetes, evaluate symptoms of low or high blood sugar, or assess conditions like hypoglycemia (low blood sugar) or hyperglycemia (high blood sugar). It can also be used to check for metabolic disorders or during pregnancy to monitor glucose metabolism.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast (not eat or drink) for 8–12 hours before the test if it’s part of a fasting glucose study. If fasting isn’t required, you can eat and drink normally. Bring any medications you’re taking to your appointment.

What Happens During the Test

A healthcare professional will draw a small amount of blood from a vein in your arm using a needle. You may feel a slight pinch, but it usually doesn’t cause significant discomfort. The blood is then sent to a lab for analysis using high-performance liquid chromatography (HPLC), a precise method to measure glucose concentration.

What the Results Mean

Results are typically reported in milligrams per deciliter (mg/dL) or millimoles per liter (mmol/L). While reference ranges vary by lab, your results will be compared to your individual baseline or clinical context. High or low values may trigger further testing or adjustments to your treatment plan.

Reference range

Fasting: 70-100 mg/dLN/A

Specimen: serum

Fasting for 8-12 hours required. Water is permitted. Avoid chewing gum and smoking before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Glucose levels in plasma are critical for diagnosing diabetes, managing blood sugar control, and detecting metabolic disorders. Persistently high or low levels can indicate conditions like diabetes mellitus, prediabetes, or reactive hypoglycemia. Regular monitoring helps prevent long-term complications such as nerve damage, kidney disease, or cardiovascular issues.

Short name

Plasma Glucose

Frequently asked questions

What causes abnormal glucose levels?
Abnormal glucose levels can result from lifestyle factors (e.g., poor diet, lack of exercise), underlying health conditions (e.g., diabetes, thyroid disorders), medications (e.g., steroids, beta-blockers), or stress. If you notice frequent symptoms like fatigue, blurred vision, or unexplained weight changes, discuss these with your provider.
How often should I get this test?
Frequency depends on your health status. People with diabetes typically check glucose levels monthly or more often as directed by their healthcare team. Others may need testing less frequently, such as every few months, based on risk factors or symptoms.
Can I eat or drink before this test?
If fasting is required, avoid food and liquids (except water) for 8–12 hours before testing. If fasting isn’t needed, eat normally. Always follow your provider’s specific instructions to ensure accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy