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Glutamate Dehydrogenase (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity level of glutamate dehydrogenase, an enzyme involved in the breakdown of amino acids and energy production in your body.

Quick summary

["GDH levels can help assess liver function and detect certain metabolic or toxic conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2362-2
Short code
Glutamate CSF-mCnc
Synonyms
Glutamate CSF-mCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Is Glutamate Dehydrogenase Used For?

Doctors may order this test to evaluate liver health, especially in cases of suspected liver damage, metabolic disorders, or exposure to toxins. It can also be part of broader metabolic screening, though it’s less commonly used than other liver function tests.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then sent to a lab where the enzyme activity is measured using a specialized chemical reaction. Results are reported in units per liter (U/L) or other standardized measurements.

When Might You Need This Test?

You might need this test if you have symptoms like fatigue, jaundice (yellowing of skin/eyes), or unexplained nausea/vomiting. It may also be part of routine monitoring for conditions like liver disease, poisoning, or metabolic disorders.

What Do the Results Mean?

Elevated levels may indicate liver damage, metabolic disorders, or exposure to toxins. Lower-than-expected levels could suggest certain metabolic or genetic conditions, but interpretation depends on clinical context and other test results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

GDH (Serum/Plasma)

Frequently asked questions

Why might my doctor order this test?
Your doctor may recommend this test if they suspect liver problems, metabolic disorders, or exposure to toxins that could affect enzyme activity. It’s sometimes used alongside other tests to get a clearer picture of your health.
What are the typical reference ranges?
Reference ranges vary by lab and method, but normal levels are generally considered below a certain threshold (often 10–50 U/L, though exact values depend on the test’s specifics). Your doctor will compare your result to your own baseline or clinical context.
Are there any risks or side effects from this test?
The most common risk is mild bruising or soreness at the needle site. Blood tests are generally safe, but if you have a bleeding disorder or take blood thinners, let your doctor know before the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy